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Sassafras Southern Bistro

Sassafras Southern Bistro, 103 N Main St #107, Greenville

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About Sassafras Southern Bistro
Sassafras Southern Bistro
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Average Price: $30 and under
Cuisine: Southern
Dress Code: Smart Casual
v < 0.1 miles from GREENVILLE center (as shown on map)

Located in the heart of downtown Greenville, South Carolina, Sassafras Southern Bistro serves an eclectic menu of American cuisine with a truly Southern influence. Menu items include steak, fresh seafood, salads, and amazing desserts. Sassafras Southern Bistro has a full bar featuring local beers on tap and an extensive wine selection both by the glass and by the bottle.





Start out your meal at Sassafras Southern Bistro with one of their amazing appetizers like the spicy pork tenderloin or the famous blue crab and pepper-jack nachos. Choose from entrees like the raved about shrimp and grits or the filet with house made pimento. Some vegetarian and gluten free options are available upon request.


Sassafras Southern Bistro Customer Reviews

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TripAdvisor Traveler Rating

Sassafras Southern Bistro is #3 of 898 things to do in Greenville

5 of 5 stars5 out of 5
By: tkeucla, Charlotte, North Carolina
Sun 12 Mar, 2023
l Hidden gem right in the heart of Greenville. The staff had out reserved take waiting for us in a packed Saturday evening. Service was excellent, both the mahi-mahi and the salmon were delicious and...

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5 of 5 stars5 out of 5
By: Bret C, Bethlehem, Georgia
Sun 5 Mar, 2023
l I was in Greenville for a conference and found this restaurant. I’m so glad I did as the food was unbelievably delicious. We had the fried green tomatoes with pimento cheese for our appetizer and I...

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5 of 5 stars5 out of 5
By: P7624QZkiml, Dade City, Florida
Wed 1 Mar, 2023
l My friend and I had a 7 pm reservation but ended up getting there at 5 due to other schedule issues and were seated with no problem. Food and drinks were delicious! When I’m Sc, you must try the...

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Sassafras Southern Bistro 103 N Main St #107, Greenville