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21c Museum Hotel St Louis

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21c Museum Hotel St Louis, 1528 Locust Street, Wellston, MO -(888) 416-0458
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4.3
HOTEL RATING: 
EXCELLENT
4.3 out of 5 (773 Ratings)
0.5 miles Enterprise Center St. Louis
v2 mins driving
t12 mins walking
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The Spotlight on 21c Museum Hotel St Louis

Art-Filled Luxury in the Heart of Downtown St. Louis

Modern, artistic, and effortlessly cool, 21c Museum Hotel St Louis is a boutique hotel located right in the center of downtown. Housed within a thoughtfully restored historic building, the hotel blends contemporary luxury with a full-fledged art museum experience. With a spa, indoor pool, and stylish rooms featuring plush seating areas and sleek bathrooms, it's a welcoming retreat just minutes from St. Louis's biggest concert venues.

Why Concert-goers love it

Location is everything, and 21c Museum Hotel St Louis delivers. It's just a short rideshare or even a walk to major venues like the Enterprise Center and The Dome at America's Center. After a late show, you'll love the 24-hour front desk and relaxed vibe. Soundproofed rooms mean you can rest peacefully after an epic night out, and the spa and hot tub offer the perfect recovery the next day.

Who this Hotel is great for

  • Groups of friends looking for a stylish, central base
  • Solo travelers checking off a bucket-list concert
  • Couples planning a romantic music-filled weekend
  • Fans who want a serene space to relax post-show
  • Budget-conscious music lovers who appreciate value and art

Food and Drink Options

The hotel's on-site restaurant serves up delicious meals, and the bar is perfect for a nightcap. Room service is available, so if you're craving a midnight snack after the concert, you're covered. Plus, with breakfast available after late nights, you won’t have to rush your morning.

Nightlife Options

The hotel’s own bar scene is lively yet relaxed, offering local craft beers and cocktails. Beyond the hotel, downtown St. Louis’s nightlife is right outside your door, with plenty of bars, lounges, and live music venues to dive into.

What People Say

Guests rave about the hotel's incredible art collection, spacious rooms, and warm, professional staff. The location earns high marks for its walkability to concerts and downtown attractions. Many reviewers mention how quiet and restful the rooms are, even in the heart of the city.

Areas for Improvement

Some guests mention that valet parking can be a bit pricey and that navigating downtown traffic during big events can be tricky. Still, most agree that the overall experience more than makes up for it.

The Bottom Line

If you're looking for a stylish, comfortable, and artful place to crash after a concert, 21c Museum Hotel St Louis hits all the right notes.
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Amenities View More
y
Free Internet
u
Swimming Pool
E
Fitness Center
w
Non Smoking
r
Pets Allowed
q
Accessible
x
Free Breakfast
j
Free Parking
A
Business Center
B
Airport Shuttle
Other Amenities
` Meeting/Banquet Facilities
` Room Service
` Safety Deposit Box
` Air Conditioning
` Bar
` 24-Hour Front Desk
` Elevator
` Coffee shop
` Hair dryer
` Coffee/tea maker
` Refrigerator
` bathrobes
` Heating
` Private check-in/check-out
` Wheelchair accessible
` indoor pool
` outdoor pool
` seating area
` vending machine
` telephone
` alarm clock
` kitchenware
` 24-hour security
` Concierge services
` Free Wi-Fi
` Game Room
` Massage services
` Restaurant(s)
` Closet
` Daily Housekeeping
` English
` Non-Smoking Rooms Available
` Parking Available
` yoga room
` Kids' pool
` Linens
` Smoke alarms
` Fire extinguishers
` Guests can opt-out of daily cleaning service
` Shared stationery such as printed menus, magazines, pens, and paper removed
` First aid kit available
` Cashless payment available
` Linens, towels and laundry washed in accordance with local authority guidelines
` Hand sanitizer in guest accommodation and key areas
` Invoices
` Staff trained in safety protocol
` Food delivery
` balcony/terrace
` ATM or cash withdraw on site
` CCTV security in common areas
` Daily disinfection
` Facilities for disabled guests available
` Fitness center
` Hot tub/Whirlpool
` Ironing amenities
` Laundry services
` Luggage storage & lockers
` Non-smoking property
` Room towels provided
` Separate shower/bathtub
` Soundproof rooms available
` Spa services
` Spa/sauna
` Toiletries provided
` TV & Movies/Shows
` Individually-wrapped food options
` Air conditioning in public area
` Heating in public area
` Alternative meal arrangement
` Desk/workspace available
` Allergy-free rooms available
` Cleaning products available
` Pets allowed (charges may apply)
` Parking available (charges may apply)
` Valet parking (charges may apply)

21c Museum Hotel St Louis Guest Reviews

Overall Average Score: 
Excellent (4.3 out of 5)

Write a review

5

Exceptional - 5.0 out of 5

Patrick Sat, 12 July 2025

Perfect staycation (we turned it...

Liked: We turned our visit into a staycation and it was amazing not having to leave the premises since there was a pool, restaurant, art museum, all in one spot.
Disliked: The steam room was not working while we were there and nobody told us that ahead of time or at checkin. Would recommend calling to make sure if all the amenities are functioning,

2.5

Fair - 2.5 out of 5

Anonymous Wed, 9 July 2025

Not great for first time...

Liked: Visually interesting
Disliked: The parking situation was uncomfortable. Wasn’t even sure we were at the main entrance (we were). Waited 30 minutes upon arrival for valet, no direction on where to check in, just no assistance and nobody interested in doing so. No room service, nothing on site after hours to grab a cold soda, nothing in walking distance. Coffee shop downstairs - employees not welcoming and clearly unhappy.

5

Exceptional - 5.0 out of 5

Epps Mon, 7 July 2025

Me and the kiddies love...

Liked: We like the swimming pool
Disliked: Nothing it was perfect

5

Exceptional - 5.0 out of 5

Khadija Mon, 7 July 2025

Great location and great amenities!...

Liked: The museum and art around the hotel really made our stay! My son is a budding artist and was truly inspired after we left. The staff took good care of us! The room was spacious… the rooms are perfectly insulated and provide a quiet night’s rest. I have no complaints. I travel often and would rank this in my top two hotel stays.
Disliked: I wish the valet was covered. That’s it.

5

Exceptional - 5.0 out of 5

Graf Sun, 6 July 2025

Exceptional

5

Exceptional - 5.0 out of 5

Russ Sat, 5 July 2025

Clean, comfortable, and downright classy!

Liked: Room wasn't ready upon arrival (understandable since we booked same day) so they comped us a $70 ticket for the bar. We had a lovely dinner on the house! Also, this was the most pet friendly facility I've ever stayed at. I've got nothing but good things to say about this place. Can't wait to go back!

4.5

Wonderful - 4.5 out of 5

Victoria Fri, 4 July 2025

Superb

5

Exceptional - 5.0 out of 5

William Fri, 4 July 2025

Exceptional

Disliked: The parking was city parking behind the hotel. They offered valet but was also street parking

5

Exceptional - 5.0 out of 5

Sophia Tue, 1 July 2025

Exceptional

4

Very Good - 4.0 out of 5

Anonymous Tue, 1 July 2025

Very good

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21c Museum Hotel St Louis 1528 Locust Street, Wellston, MO